In:
The Journal of Immunology, The American Association of Immunologists, Vol. 200, No. 1_Supplement ( 2018-05-01), p. 178.40-178.40
Abstract:
Compelling evidence has suggested the pivotal role of immune cells in the development of carcinogenesis and metastasis in pancreatic cancer (PC). Interrogation on the cell diversity is essential to delineate the tumor microenvironment and the cross-talks between immune cells and tumor. In this study, we systemically profiled single-cell transcriptomes at various stages of PC and found that malignant cells between tumors expressed varied gene repertoire related to proliferation and differentiation. Interestingly, fibroblasts, pancreatic stellate cells and vascular cells also displayed heterogeneity in cell composition and gene signatures, potentially leading to varied degrees of desmoplastic reaction. Strikingly, such dynamics in desmoplastic reaction was evidently associated with the enrichment of specific subsets of immune cells, providing rich resources for detailed mechanistic studies. Our analyses highlighted the connection between infiltrated immune cells and tumor cells and provided insight into the cellular cross-talk of PC at single-cell resolution. Results from this study will also further our understanding of immune landscape in PC with implications for therapeutic development.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.200.Supp.178.40
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2018
detail.hit.zdb_id:
1475085-5
