In:
Breast Cancer: Basic and Clinical Research, SAGE Publications, Vol. 9 ( 2015-01), p. BCBCR.S27534-
Kurzfassung:
Adding platinum drugs to anthracycline/taxane (ANC-Tax)-based neoadjuvant chemotherapy (NAC) improves pathological complete response (pCR) rates in triple-negative breast cancer (TNBC). Copper transporter 1 (CTR1) and organic cation transporter 2 (OCT2) critically affect the uptake and cytotoxicity of platinum drugs. We immunohistochemically determined CTR1 and OCT2 levels in pre-chemotherapy biopsies from 105 patients with HER2-negative breast cancer treated with ANC-Tax-based NAC. In the TNBC group, Ki-67 high [pathological good response (pGR), P = 0.04] was associated with response, whereas CTR1 high (non-pGR, P = 0.03), OCT2 high (non-pGR, P = 0.01; non-pCR, P = 0.03), and combined CTR1 high and/or OCT2 high (non-pGR, P = 0.005; non-pCR, P = 0.003) were associated with non-response. In multivariate analysis, Ki-67 high was an independent factor for pGR and CTR1 for non-pGR. Combined CTR1/OCT2 was a strong independent factor for non-pGR. However, no variables were associated with response in luminal BC. These results indicate that platinum uptake transporters are predominantly expressed in ANC-Tax-resistant TNBCs, which implies that advantage associated with adding platinum drugs may depend on high drug uptake.
Materialart:
Online-Ressource
ISSN:
1178-2234
,
1178-2234
DOI:
10.4137/BCBCR.S27534
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2015
ZDB Id:
2423804-1
