In:
Future Medicinal Chemistry, Future Science Ltd, Vol. 4, No. 9 ( 2012-06), p. 1067-1084
Kurzfassung:
Natural products (NPs) have historically been a fertile source of new drugs for the pharmaceutical industry. However, this once-popular approach has waned considerably over the past two decades as the high-throughput screening of megalibraries comprised mainly of molecules with non-natural (synthetic) motifs has unfolded. Contemporary high-throughput screening libraries contain molecules compliant with physicochemical profiles considered essential for downstream development. Until recently, there was no strategy that aligned NP screening with the same physicochemical profiles. An approach based on Log P has addressed these concerns and, together with advances in isolation, afforded NP leads in timelines compatible with pure compound screening. Concomitant progress related to access of biological resources has provided long-awaited legal certainty to further facilitate NP drug discovery.
Materialart:
Online-Ressource
ISSN:
1756-8919
,
1756-8927
Sprache:
Englisch
Verlag:
Future Science Ltd
Publikationsdatum:
2012
SSG:
15,3
