In:
Bulletin de l'Académie Vétérinaire de France, PERSEE Program, Vol. 159, No. 2 ( 2006), p. 137-140
Abstract:
The eye of laboratory animals in drug safety evaluation Ophthalmologic examinations in laboratory animals are based on the same principle as that used in species routinely treated in veterinary practice. The main laboratory animal species used in toxicology studies are rodents (mostly rats and sometimes mice) as well as beagles and macaques (cynomolgus), and less frequently marmosets or mini-pigs. A sound knowledge of the morphological and functional characteristics, as well as of the spontaneous ocular anomalies found in each species is imperative to assess the potential ocular toxicity of a product. Macroscopic examination of the different eye segments, as well as microscopic examination are systematically performed in regulatory toxicity studies, using well-defined methodology and frequency. Further studies may be added to these routine examinations, based on the product’s pharmacological activity, or on ocular changes observed in animals or in human patients. Two examples of mechanistic studies illustrate the variety of available techniques and models : investigation of cataractogenic potential of a drug in a co-cataractogenesis study in rats ; and identification of an effect on retinal function using electroretinography.
Type of Medium:
Online Resource
ISSN:
0001-4192
Language:
French
Publisher:
PERSEE Program
Publication Date:
2006
detail.hit.zdb_id:
2840771-4
SSG:
22
