In:
Journal of the chemical society of pakistan, Chemical Society of Pakistan, Vol. 43, No. 5 ( 2021), p. 598-598
Abstract:
Excessive accumulation of free radicals can cause a variety of diseases. According to reports, chalcone has the activity of scavenging free radicals. In this study, we synthesized a chalcone derivative CZM-3-5 and evaluated its antioxidant activity using a chemical assessment method (2,2and#39;-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS•+) assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) assay and total reducing antioxidant power (FRAP) assay) and a cell model of oxidative damage induced by hydrogen peroxide (H2O2). The chemical evaluation results show that the compound CZM-3-5 has good antioxidant capacity and free radical scavenging ability. MTT analysis showed that the compound has cytoprotective activity in H2O2-induced PC12 cells, and the mechanism may be related to the cytoprotective substance superoxide dismutase (SOD) is related to the level of glutathione (GSH). Overall, our findings indicate that compound CZM-3-5 has potential antioxidant activity in vitro.
Type of Medium:
Online Resource
ISSN:
0253-5106
Uniform Title:
Design, Synthesis and Antioxidant Activity of Chalcone Derivative CMZ-3-5
Language:
Unknown
Publisher:
Chemical Society of Pakistan
Publication Date:
2021
detail.hit.zdb_id:
3024078-5
