In:
Journal of the chemical society of pakistan, Chemical Society of Pakistan, Vol. 41, No. 1 ( 2019), p. 186-186
Abstract:
A series of novel 6-substituted quinazoline derivatives were synthesised as epidermal growth factor receptor(EGFR) and Human epidermal growth factor receptor 2 (HER2)inhibitors in our lab. The novel compounds were measured for their dual enzyme inhibition as well as their cytotoxic activity on MCF7 cell line. The results revealed that all the compounds showed inhibition of both enzymes. Compound 5c showed the best inhibitory activity against both enzymes and IC50 of its was 2.6 nM against EGFR kinases and 4.3 nM against HER2 kinases, respectively. Most of the measured compounds showed to antitumor activity on MCF7.
Type of Medium:
Online Resource
ISSN:
0253-5106
Uniform Title:
Synthesis and Evaluation of Some Novel 6-Substituted Quinazoline Derivatives as Antitumor Agents
DOI:
10.52568/000716/JCSP/41.01.2019
Language:
Unknown
Publisher:
Chemical Society of Pakistan
Publication Date:
2019
detail.hit.zdb_id:
3024078-5