In:
The International Journal of Biological Markers, SAGE Publications, Vol. 28, No. 1 ( 2013-01), p. 3-16
Abstract:
Circulating estrogens are associated with increased breast cancer risk, yet the role of estrogen metabolites in breast carcinogenesis remains unclear. This combined analysis of 5 published studies evaluates urinary 2-hydroxyestrone (2-OHE 1 ), 16α-hydroxyestrone (16α-OHE 1 ), and their ratio (2:16α-OHE 1 ) in relation to breast cancer risk. Methods Primary data on 726 premenopausal women (183 invasive breast cancer cases and 543 controls) and 1,108 postmenopausal women (385 invasive breast cancer cases and 723 controls) were analyzed. Urinary estrogen metabolites were measured using enzyme linked immunosorbent assays. Study-specific and combined multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated based on tertiles of estrogen metabolites. Multinomial logistic regression models were fit according to hormone receptor status. Results Higher premenopausal 2:16α-OHE 1 was suggestive of reduced breast cancer risk overall (study-adjusted OR IIIvsI =0.80; 95% CI: 0.49-1.32) and for estrogen receptor negative (ER-) subtype (OR IIIvsI =0.33; 95% CI: 0.13-0.84). Among postmenopausal women, 2:16α-OHE 1 was unrelated to breast cancer risk (study-adjusted OR IIIvsI =0.93; 95% CI: 0.65-1.33); however, the association between 2-OHE 1 and risk varied by body mass index (p-interaction=0.003). Conclusions Premenopausal urinary 2:16α-OHE 1 may play a role in breast carcinogenesis; however, larger studies are needed. Our findings do not support reduced breast cancer risk with higher postmenopausal 2:16α-OHE 1 overall, although obesity may modify associations with 2-OHE 1 .
Type of Medium:
Online Resource
ISSN:
1724-6008
,
1724-6008
DOI:
10.5301/JBM.2012.9353
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
detail.hit.zdb_id:
1475778-3
