In:
Asian Biomedicine, Walter de Gruyter GmbH, Vol. 9, No. 2 ( 2017-1-31), p. 147-154
Kurzfassung:
The relationship between endothelial dysfunction, a risk factor for coronary artery disease, and the incidence of cardiovascular disease (CVD) in the general population is not well known. Objectives To determine the utility of an exercise treadmill test (ETT) combined with inflammatory markers to show endothelial dysfunction for individuals with a low risk of adverse cardiovascular (CV) events. Methods Biomarkers of inflammation (lipoprotein-related phospholipase A 2 (Lp-PLA 2 ) and high-sensitive C-reactive protein (hs-CRP)) and biomarkers of endothelial dysfunction (nitric oxide, oxidized low-density lipoprotein (Ox-LDL), and sialic acid) were assessed in 60 apparently healthy patients with a positive (+) or negative (−) ETT and across endothelial function assessed by flow mediated dilatation (FMD) and Lp-PLA 2 tertiles. Results Lp-PLA 2 levels were increased in ETT (−) compared with ETT (+) patients. Half of ETT (−) patients were found to have levels of Lp-PLA 2 in the highest tertile. There was a significant inverse relationship between ETT and inflammatory biomarkers when adjusted for age, Lp-PLA 2 ( r = −0.28, P = 0.04), or hs-CRP ( r = −0.35, P = 0.01). No differences were found for biomarkers of endothelial dysfunction. All variables were reassessed across FMD tertiles. Total lipids, Ox-LDL, triglyceride, and Lp-PLA 2 were higher for the lowest FMD tertile. Conclusion The elevation of Lp-PLA 2 in ETT (−) patients and the inverse relationship with inflammatory biomarkers, suggest that ETT cannot address endothelial dysfunction for individuals with apparently low risk of adverse CV events, and cannot be used for risk stratification of the general population.
Materialart:
Online-Ressource
ISSN:
1875-855X
DOI:
10.5372/1905-7415.0902.380
Sprache:
Englisch
Verlag:
Walter de Gruyter GmbH
Publikationsdatum:
2017
ZDB Id:
2583850-7
