In:
Archives of Pathology & Laboratory Medicine, Archives of Pathology and Laboratory Medicine, Vol. 128, No. 2 ( 2004-02-01), p. 187-190
Abstract:
Context.—Previous studies have shown that loss of the X chromosome is involved in the carcinogenesis of certain human malignancies. Objective.—To determine whether X-linked allelic losses occur during bladder tumorigenesis and whether such losses involve the active or the inactive X chromosome. Design.—We analyzed the deletion status of the X-linked human androgen receptor gene locus in 6 female patients who underwent radical cystectomies for muscle-invasive urothelial carcinoma of the urinary bladder. Four patients had coexisting urothelial carcinoma in situ. Analysis for inactivation of the X chromosome was carried out in parallel. Results.—Three cases were informative. Invasive tumor samples showed loss of heterozygosity involving the active allele at the androgen receptor locus in all 3 positive cases, whereas carcinoma in situ showed nonrandom X chromosome inactivation but not allelic deletion. Conclusions.—Our data suggest that allelic loss of the activated X chromosome is involved in bladder carcinogenesis and cancer progression.
Type of Medium:
Online Resource
ISSN:
1543-2165
,
0003-9985
DOI:
10.5858/2004-128-187-ALOTAX
Language:
English
Publisher:
Archives of Pathology and Laboratory Medicine
Publication Date:
2004
detail.hit.zdb_id:
2028916-9
