In:
eLife, eLife Sciences Publications, Ltd, Vol. 4 ( 2015-07-11)
Abstract:
The itchy-scratchy misery of a chickenpox was until recently a rite of passage for children around the world. The varicella-zoster virus causes chickenpox infections. This virus persists in small numbers in nerve cells for many years after infection, and can reactivate from these cells. Often this reactivation causes no symptoms, but sometimes it results in a painful skin condition called shingles (or herpes zoster), especially in older adults. Some countries—including the United States, Australia, Taiwan and Greece—have virtually wiped out childhood cases of chickenpox by requiring that children be vaccinated against the varicella-zoster virus. But some countries have hesitated. One reason for this hesitation is that exposure to individuals with a chickenpox infection helps boost the immunity of individuals who have previously been infected. This may help reduce the likelihood of these people developing shingles later in life. So, some countries have worried that chickenpox vaccinations might inadvertently increase the number of shingles cases. To assess this risk, many scientists have created computer models, but the models have some limitations. Now, Ogunjimi et al. report a new individual-based model to assess the effect of childhood varicella vaccination on shingles cases that factors in the immune responses to varicella infection. The model suggests that re-exposure to the varicella virus through contact with infected people would only provide extra protection for about two years; this is much shorter than previous predictions that suggested it might last 20 years. The model also predicts that implementing a varicella vaccination program for children would almost double the number of shingles cases 31 years later. But this increase would be temporary. The predicted increase in shingles cases is likely to disproportionately occur among 31- to 40-year-olds. This is unexpected because most previous models predict that older age groups would bear the brunt of a rise in shingles, but this younger population would be less likely to develop lasting complications of shingles. Together, these findings may allay some fears about implementing childhood varicella vaccination programs by showing that the benefits of re-exposure are limited.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.07116.001
DOI:
10.7554/eLife.07116.002
DOI:
10.7554/eLife.07116.003
DOI:
10.7554/eLife.07116.004
DOI:
10.7554/eLife.07116.005
DOI:
10.7554/eLife.07116.006
DOI:
10.7554/eLife.07116.007
DOI:
10.7554/eLife.07116.008
DOI:
10.7554/eLife.07116.009
DOI:
10.7554/eLife.07116.010
DOI:
10.7554/eLife.07116.011
DOI:
10.7554/eLife.07116.012
DOI:
10.7554/eLife.07116.013
DOI:
10.7554/eLife.07116.014
DOI:
10.7554/eLife.07116.015
DOI:
10.7554/eLife.07116.016
DOI:
10.7554/eLife.07116.017
DOI:
10.7554/eLife.07116.018
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2015
detail.hit.zdb_id:
2687154-3