In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-12-18)
Abstract:
Odor-preferences are usually influenced by life experiences. However, the neural circuit mechanisms remain unclear. The medial olfactory tubercle (mOT) is involved in both reward and olfaction, whereas the ventral tegmental area (VTA) dopaminergic (DAergic) neurons are considered to be engaged in reward and motivation. Here, we found that the VTA (DAergic)-mOT pathway could be activated by different types of naturalistic rewards as well as odors in DAT-cre mice. Optogenetic activation of the VTA-mOT DAergic fibers was able to elicit preferences for space, location and neutral odor, while pharmacological blockade of the dopamine receptors in the mOT fully prevented the odor-preference formation. Furthermore, inactivation of the mOT-projecting VTA DAergic neurons eliminated the previously formed odor-preference and strongly affected the Go-no go learning efficiency. In summary, our results revealed that the VTA (DAergic)-mOT pathway mediates a variety of naturalistic reward processes and different types of preferences including odor-preference in mice.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.25423.001
DOI:
10.7554/eLife.25423.002
DOI:
10.7554/eLife.25423.003
DOI:
10.7554/eLife.25423.004
DOI:
10.7554/eLife.25423.007
DOI:
10.7554/eLife.25423.005
DOI:
10.7554/eLife.25423.006
DOI:
10.7554/eLife.25423.008
DOI:
10.7554/eLife.25423.010
DOI:
10.7554/eLife.25423.009
DOI:
10.7554/eLife.25423.011
DOI:
10.7554/eLife.25423.012
DOI:
10.7554/eLife.25423.013
DOI:
10.7554/eLife.25423.014
DOI:
10.7554/eLife.25423.015
DOI:
10.7554/eLife.25423.016
DOI:
10.7554/eLife.25423.017
DOI:
10.7554/eLife.25423.018
DOI:
10.7554/eLife.25423.019
DOI:
10.7554/eLife.25423.020
DOI:
10.7554/eLife.25423.021
DOI:
10.7554/eLife.25423.022
DOI:
10.7554/eLife.25423.023
DOI:
10.7554/eLife.25423.025
DOI:
10.7554/eLife.25423.024
DOI:
10.7554/eLife.25423.026
DOI:
10.7554/eLife.25423.027
DOI:
10.7554/eLife.25423.028
DOI:
10.7554/eLife.25423.030
DOI:
10.7554/eLife.25423.031
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3