In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-08-01)
Kurzfassung:
Satiety-signaling, pro-opiomelanocortin (POMC)-expressing neurons in the arcuate nucleus of the hypothalamus play a pivotal role in the regulation of energy homeostasis. Recent studies reported altered mitochondrial dynamics and decreased mitochondria- endoplasmic reticulum contacts in POMC neurons during diet-induced obesity. Since mitochondria play a crucial role in Ca2+ signaling, we investigated whether obesity alters Ca2+ handling of these neurons in mice. In diet-induced obesity, cellular Ca2+ handling properties including mitochondrial Ca2+ uptake capacity are impaired, and an increased resting level of free intracellular Ca2+ is accompanied by a marked decrease in neuronal excitability. Experimentally increasing or decreasing intracellular Ca2+ concentrations reproduced electrophysiological properties observed in diet-induced obesity. Taken together, we provide the first direct evidence for a diet-dependent deterioration of Ca2+ homeostasis in POMC neurons during obesity development resulting in impaired function of these critical energy homeostasis-regulating neurons.
Materialart:
Online-Ressource
ISSN:
2050-084X
DOI:
10.7554/eLife.25641.001
DOI:
10.7554/eLife.25641.002
DOI:
10.7554/eLife.25641.003
DOI:
10.7554/eLife.25641.004
DOI:
10.7554/eLife.25641.005
DOI:
10.7554/eLife.25641.006
DOI:
10.7554/eLife.25641.007
DOI:
10.7554/eLife.25641.008
DOI:
10.7554/eLife.25641.009
DOI:
10.7554/eLife.25641.010
DOI:
10.7554/eLife.25641.011
DOI:
10.7554/eLife.25641.012
Sprache:
Englisch
Verlag:
eLife Sciences Publications, Ltd
Publikationsdatum:
2017
ZDB Id:
2687154-3
