In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-12-07)
Abstract:
Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a comparative transcriptomic dataset of replicating liver schizonts and dormant hypnozoites of the relapsing parasite Plasmodium cynomolgi. Hypnozoites express only 34% of Plasmodium physiological pathways, while 91% are expressed in replicating schizonts. Few known malaria drug targets are expressed in quiescent parasites, but pathways involved in microbial dormancy, maintenance of genome integrity and ATP homeostasis were robustly expressed. Several transcripts encoding heavy metal transporters were expressed in hypnozoites and the copper chelator neocuproine was cidal to all liver stage parasites. This transcriptomic dataset is a valuable resource for the discovery of vaccines and effective treatments to combat vivax malaria.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.29605.001
DOI:
10.7554/eLife.29605.002
DOI:
10.7554/eLife.29605.003
DOI:
10.7554/eLife.29605.004
DOI:
10.7554/eLife.29605.005
DOI:
10.7554/eLife.29605.006
DOI:
10.7554/eLife.29605.007
DOI:
10.7554/eLife.29605.008
DOI:
10.7554/eLife.29605.009
DOI:
10.7554/eLife.29605.010
DOI:
10.7554/eLife.29605.011
DOI:
10.7554/eLife.29605.012
DOI:
10.7554/eLife.29605.013
DOI:
10.7554/eLife.29605.014
DOI:
10.7554/eLife.29605.015
DOI:
10.7554/eLife.29605.016
DOI:
10.7554/eLife.29605.017
DOI:
10.7554/eLife.29605.018
DOI:
10.7554/eLife.29605.019
DOI:
10.7554/eLife.29605.020
DOI:
10.7554/eLife.29605.021
DOI:
10.7554/eLife.29605.022
DOI:
10.7554/eLife.29605.023
DOI:
10.7554/eLife.29605.024
DOI:
10.7554/eLife.29605.030
DOI:
10.7554/eLife.29605.031
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3