In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-03-13)
Kurzfassung:
Sleep-like states in diverse organisms can be separated into distinct stages, each with a characteristic arousal threshold. However, the molecular pathways underlying different sleep stages remain unclear. The fruit fly, Drosophila melanogaster, exhibits consolidated sleep during both day and night, with night sleep associated with higher arousal thresholds compared to day sleep. Here we identify a role for the neuronal calcium sensor protein Neurocalcin (NCA) in promoting sleep during the night but not the day by suppressing nocturnal arousal and hyperactivity. We show that both circadian and light-sensing pathways define the temporal window in which NCA promotes sleep. Furthermore, we find that NCA promotes sleep by suppressing synaptic release from a dispersed wake-promoting neural network and demonstrate that the mushroom bodies, a sleep-regulatory center, are a module within this network. Our results advance the understanding of how sleep stages are genetically defined.
Materialart:
Online-Ressource
ISSN:
2050-084X
DOI:
10.7554/eLife.38114.001
DOI:
10.7554/eLife.38114.002
DOI:
10.7554/eLife.38114.011
DOI:
10.7554/eLife.38114.003
DOI:
10.7554/eLife.38114.004
DOI:
10.7554/eLife.38114.005
DOI:
10.7554/eLife.38114.006
DOI:
10.7554/eLife.38114.007
DOI:
10.7554/eLife.38114.008
DOI:
10.7554/eLife.38114.009
DOI:
10.7554/eLife.38114.010
DOI:
10.7554/eLife.38114.012
DOI:
10.7554/eLife.38114.013
DOI:
10.7554/eLife.38114.014
DOI:
10.7554/eLife.38114.015
DOI:
10.7554/eLife.38114.016
DOI:
10.7554/eLife.38114.019
DOI:
10.7554/eLife.38114.017
DOI:
10.7554/eLife.38114.018
DOI:
10.7554/eLife.38114.020
DOI:
10.7554/eLife.38114.023
DOI:
10.7554/eLife.38114.021
DOI:
10.7554/eLife.38114.022
DOI:
10.7554/eLife.38114.024
DOI:
10.7554/eLife.38114.025
DOI:
10.7554/eLife.38114.026
DOI:
10.7554/eLife.38114.027
DOI:
10.7554/eLife.38114.028
DOI:
10.7554/eLife.38114.029
DOI:
10.7554/eLife.38114.030
DOI:
10.7554/eLife.38114.042
DOI:
10.7554/eLife.38114.043
DOI:
10.7554/eLife.38114.032
DOI:
10.7554/eLife.38114.033
DOI:
10.7554/eLife.38114.034
DOI:
10.7554/eLife.38114.035
DOI:
10.7554/eLife.38114.036
DOI:
10.7554/eLife.38114.037
DOI:
10.7554/eLife.38114.038
DOI:
10.7554/eLife.38114.039
DOI:
10.7554/eLife.38114.040
DOI:
10.7554/eLife.38114.041
Sprache:
Englisch
Verlag:
eLife Sciences Publications, Ltd
Publikationsdatum:
2019
ZDB Id:
2687154-3
