In:
eLife, eLife Sciences Publications, Ltd, Vol. 7 ( 2018-10-25)
Abstract:
The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive. Here we show transcriptional and anatomical contributions of compartmentalized epidermal stem cells in tactile sensory unit formation in the mouse hair follicle. Epidermal stem cells in the follicle upper-bulge, where mechanosensory lanceolate complexes innervate, express a unique set of extracellular matrix (ECM) and neurogenesis-related genes. These epidermal stem cells deposit an ECM protein called EGFL6 into the collar matrix, a novel ECM that tightly ensheathes lanceolate complexes. EGFL6 is required for the proper patterning, touch responses, and αv integrin-enrichment of lanceolate complexes. By maintaining a quiescent original epidermal stem cell niche, the old bulge, epidermal stem cells provide anatomically stable follicle–lanceolate complex interfaces, irrespective of the stage of follicle regeneration cycle. Thus, compartmentalized epidermal stem cells provide a niche linking the hair follicle and the nervous system throughout the hair cycle.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.38883.001
DOI:
10.7554/eLife.38883.002
DOI:
10.7554/eLife.38883.004
DOI:
10.7554/eLife.38883.005
DOI:
10.7554/eLife.38883.003
DOI:
10.7554/eLife.38883.006
DOI:
10.7554/eLife.38883.008
DOI:
10.7554/eLife.38883.009
DOI:
10.7554/eLife.38883.007
DOI:
10.7554/eLife.38883.010
DOI:
10.7554/eLife.38883.011
DOI:
10.7554/eLife.38883.012
DOI:
10.7554/eLife.38883.018
DOI:
10.7554/eLife.38883.013
DOI:
10.7554/eLife.38883.014
DOI:
10.7554/eLife.38883.015
DOI:
10.7554/eLife.38883.016
DOI:
10.7554/eLife.38883.017
DOI:
10.7554/eLife.38883.019
DOI:
10.7554/eLife.38883.020
DOI:
10.7554/eLife.38883.021
DOI:
10.7554/eLife.38883.024
DOI:
10.7554/eLife.38883.022
DOI:
10.7554/eLife.38883.023
DOI:
10.7554/eLife.38883.025
DOI:
10.7554/eLife.38883.026
DOI:
10.7554/eLife.38883.027
DOI:
10.7554/eLife.38883.031
DOI:
10.7554/eLife.38883.032
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2018
detail.hit.zdb_id:
2687154-3