In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-01-29)
Kurzfassung:
Dendritic arbors are crucial for nervous system assembly, but the intracellular mechanisms that govern their assembly remain incompletely understood. Here, we show that the dendrites of PVD neurons in Caenorhabditis elegans are patterned by distinct pathways downstream of the DMA-1 leucine-rich transmembrane (LRR-TM) receptor. DMA-1/LRR-TM interacts through a PDZ ligand motif with the guanine nucleotide exchange factor TIAM-1/GEF in a complex with act-4/Actin to pattern higher order 4° dendrite branches by localizing F-actin to the distal ends of developing dendrites. Surprisingly, TIAM-1/GEF appears to function independently of Rac1 guanine nucleotide exchange factor activity. A partially redundant pathway, dependent on HPO-30/Claudin, regulates formation of 2° and 3° branches, possibly by regulating membrane localization and trafficking of DMA-1/LRR-TM. Collectively, our experiments suggest that HPO-30/Claudin localizes the DMA-1/LRR-TM receptor on PVD dendrites, which in turn can control dendrite patterning by directly modulating F-actin dynamics through TIAM-1/GEF.
Materialart:
Online-Ressource
ISSN:
2050-084X
DOI:
10.7554/eLife.38949.001
DOI:
10.7554/eLife.38949.002
DOI:
10.7554/eLife.38949.003
DOI:
10.7554/eLife.38949.004
DOI:
10.7554/eLife.38949.005
DOI:
10.7554/eLife.38949.006
DOI:
10.7554/eLife.38949.007
DOI:
10.7554/eLife.38949.008
DOI:
10.7554/eLife.38949.009
DOI:
10.7554/eLife.38949.010
DOI:
10.7554/eLife.38949.011
DOI:
10.7554/eLife.38949.012
DOI:
10.7554/eLife.38949.013
DOI:
10.7554/eLife.38949.014
DOI:
10.7554/eLife.38949.015
DOI:
10.7554/eLife.38949.016
DOI:
10.7554/eLife.38949.023
DOI:
10.7554/eLife.38949.024
DOI:
10.7554/eLife.38949.020
DOI:
10.7554/eLife.38949.021
Sprache:
Englisch
Verlag:
eLife Sciences Publications, Ltd
Publikationsdatum:
2019
ZDB Id:
2687154-3