In:
eLife, eLife Sciences Publications, Ltd, Vol. 7 ( 2018-10-03)
Abstract:
How are decisions made between different goods? One theory spanning several fields of neuroscience proposes that their values are distilled to a single common neural currency, the calculation of which allows for rational decisions. The orbitofrontal cortex (OFC) is thought to play a critical role in this process, based on the presence of neural correlates of economic value in lateral OFC in monkeys and medial OFC in humans. We previously inactivated lateral OFC in rats without affecting economic choice behavior. Here we inactivated medial OFC in the same task, again without effect. Behavior in the same rats was disrupted by inactivation during progressive ratio responding previously shown to depend on medial OFC, demonstrating the efficacy of the inactivation. These results indicate that medial OFC is not necessary for economic choice, bolstering the proposal that classic economic choice is likely mediated by multiple, overlapping neural circuits.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.38963.001
DOI:
10.7554/eLife.38963.002
DOI:
10.7554/eLife.38963.003
DOI:
10.7554/eLife.38963.004
DOI:
10.7554/eLife.38963.005
DOI:
10.7554/eLife.38963.007
DOI:
10.7554/eLife.38963.006
DOI:
10.7554/eLife.38963.008
DOI:
10.7554/eLife.38963.010
DOI:
10.7554/eLife.38963.009
DOI:
10.7554/eLife.38963.011
DOI:
10.7554/eLife.38963.012
DOI:
10.7554/eLife.38963.013
DOI:
10.7554/eLife.38963.014
DOI:
10.7554/eLife.38963.015
DOI:
10.7554/eLife.38963.016
DOI:
10.7554/eLife.38963.017
DOI:
10.7554/eLife.38963.018
DOI:
10.7554/eLife.38963.020
DOI:
10.7554/eLife.38963.021
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2018
detail.hit.zdb_id:
2687154-3
