In:
eLife, eLife Sciences Publications, Ltd, Vol. 7 ( 2018-12-17)
Abstract:
Reactive oxygen species (ROS) have been extensively studied as damaging agents associated with ageing and neurodegenerative conditions. Their role in the nervous system under non-pathological conditions has remained poorly understood. Working with the Drosophila larval locomotor network, we show that in neurons ROS act as obligate signals required for neuronal activity-dependent structural plasticity, of both pre- and postsynaptic terminals. ROS signaling is also necessary for maintaining evoked synaptic transmission at the neuromuscular junction, and for activity-regulated homeostatic adjustment of motor network output, as measured by larval crawling behavior. We identified the highly conserved Parkinson’s disease-linked protein DJ-1β as a redox sensor in neurons where it regulates structural plasticity, in part via modulation of the PTEN-PI3Kinase pathway. This study provides a new conceptual framework of neuronal ROS as second messengers required for neuronal plasticity and for network tuning, whose dysregulation in the ageing brain and under neurodegenerative conditions may contribute to synaptic dysfunction.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.39393.001
DOI:
10.7554/eLife.39393.002
DOI:
10.7554/eLife.39393.003
DOI:
10.7554/eLife.39393.004
DOI:
10.7554/eLife.39393.005
DOI:
10.7554/eLife.39393.006
DOI:
10.7554/eLife.39393.010
DOI:
10.7554/eLife.39393.007
DOI:
10.7554/eLife.39393.008
DOI:
10.7554/eLife.39393.009
DOI:
10.7554/eLife.39393.011
DOI:
10.7554/eLife.39393.012
DOI:
10.7554/eLife.39393.013
DOI:
10.7554/eLife.39393.014
DOI:
10.7554/eLife.39393.015
DOI:
10.7554/eLife.39393.016
DOI:
10.7554/eLife.39393.017
DOI:
10.7554/eLife.39393.018
DOI:
10.7554/eLife.39393.020
DOI:
10.7554/eLife.39393.021
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2018
detail.hit.zdb_id:
2687154-3
