In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-08-06)
Abstract:
Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.39495.001
DOI:
10.7554/eLife.39495.002
DOI:
10.7554/eLife.39495.003
DOI:
10.7554/eLife.39495.004
DOI:
10.7554/eLife.39495.005
DOI:
10.7554/eLife.39495.006
DOI:
10.7554/eLife.39495.007
DOI:
10.7554/eLife.39495.008
DOI:
10.7554/eLife.39495.009
DOI:
10.7554/eLife.39495.010
DOI:
10.7554/eLife.39495.011
DOI:
10.7554/eLife.39495.012
DOI:
10.7554/eLife.39495.013
DOI:
10.7554/eLife.39495.014
DOI:
10.7554/eLife.39495.015
DOI:
10.7554/eLife.39495.016
DOI:
10.7554/eLife.39495.017
DOI:
10.7554/eLife.39495.018
DOI:
10.7554/eLife.39495.019
DOI:
10.7554/eLife.39495.020
DOI:
10.7554/eLife.39495.021
DOI:
10.7554/eLife.39495.022
DOI:
10.7554/eLife.39495.023
DOI:
10.7554/eLife.39495.024
DOI:
10.7554/eLife.39495.025
DOI:
10.7554/eLife.39495.026
DOI:
10.7554/eLife.39495.027
DOI:
10.7554/eLife.39495.028
DOI:
10.7554/eLife.39495.032
DOI:
10.7554/eLife.39495.033
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2019
detail.hit.zdb_id:
2687154-3
