In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-03-26)
Kurzfassung:
Proteins, the workhorses of the body, participate in virtually every single process in a cell. Different types of molecules, such as sugars, can be added onto a protein to change its role or location, but this process may also play a role in cancer. Indeed, tumor cells that contain certain sugar modifications are more likely to be able to spread through the body. For example, a specific combination of sugars called T antigen is rarely present in healthy adult cells; yet, it is commonly found in cancer cells that leave the tumor where they were born and invade another tissue to form a new tumor. However, it is not clear whether T antigen actively helps this process inside the body, or is simply present during it. To answer this question, Valosková, Biebl et al. used genetic and biochemistry tools to study developing fruit fly embryos, where certain immune cells carry T antigen on their proteins. Like invading cancer cells, these immune cells can get inside tissues during development. The experiments revealed that a protein called Minerva helps attach T antigen onto proteins. When embryos were engineered to contain less Minerva, the amount of T antigen in the immune cells dropped, and the cells could not easily make their way into tissues anymore. When the mouse version of Minerva was then added to the embryos, the immune cells of the fruit flies had higher T antigen levels on their proteins and could invade tissues again. Some of the proteins targeted by Minerva were known to be involved in cancer, but not all of them. Future experiments will investigate which role the human version of Minerva plays in cancer cells that get inside new tissues, and if it could help us predict whether a cancer is likely to spread.
Materialart:
Online-Ressource
ISSN:
2050-084X
DOI:
10.7554/eLife.41801.001
DOI:
10.7554/eLife.41801.002
DOI:
10.7554/eLife.41801.003
DOI:
10.7554/eLife.41801.005
DOI:
10.7554/eLife.41801.004
DOI:
10.7554/eLife.41801.006
DOI:
10.7554/eLife.41801.008
DOI:
10.7554/eLife.41801.007
DOI:
10.7554/eLife.41801.009
DOI:
10.7554/eLife.41801.011
DOI:
10.7554/eLife.41801.010
DOI:
10.7554/eLife.41801.012
DOI:
10.7554/eLife.41801.013
DOI:
10.7554/eLife.41801.014
DOI:
10.7554/eLife.41801.016
DOI:
10.7554/eLife.41801.017
DOI:
10.7554/eLife.41801.018
DOI:
10.7554/eLife.41801.020
DOI:
10.7554/eLife.41801.019
DOI:
10.7554/eLife.41801.021
DOI:
10.7554/eLife.41801.022
DOI:
10.7554/eLife.41801.024
DOI:
10.7554/eLife.41801.023
DOI:
10.7554/eLife.41801.025
DOI:
10.7554/eLife.41801.026
DOI:
10.7554/eLife.41801.027
DOI:
10.7554/eLife.41801.028
DOI:
10.7554/eLife.41801.031
DOI:
10.7554/eLife.41801.032
Sprache:
Englisch
Verlag:
eLife Sciences Publications, Ltd
Publikationsdatum:
2019
ZDB Id:
2687154-3