In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-01-16)
Abstract:
Myelination requires extensive plasma membrane rearrangements, implying that molecules controlling membrane dynamics play prominent roles. The large GTPase dynamin 2 (DNM2) is a well-known regulator of membrane remodeling, membrane fission, and vesicular trafficking. Here, we genetically ablated Dnm2 in Schwann cells (SCs) and in oligodendrocytes of mice. Dnm2 deletion in developing SCs resulted in severely impaired axonal sorting and myelination onset. Induced Dnm2 deletion in adult SCs caused a rapidly-developing peripheral neuropathy with abundant demyelination. In both experimental settings, mutant SCs underwent prominent cell death, at least partially due to cytokinesis failure. Strikingly, when Dnm2 was deleted in adult SCs, non-recombined SCs still expressing DNM2 were able to remyelinate fast and efficiently, accompanied by neuropathy remission. These findings reveal a remarkable self-healing capability of peripheral nerves that are affected by SC loss. In the central nervous system, however, we found no major defects upon Dnm2 deletion in oligodendrocytes.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.42404.001
DOI:
10.7554/eLife.42404.002
DOI:
10.7554/eLife.42404.003
DOI:
10.7554/eLife.42404.004
DOI:
10.7554/eLife.42404.006
DOI:
10.7554/eLife.42404.005
DOI:
10.7554/eLife.42404.007
DOI:
10.7554/eLife.42404.013
DOI:
10.7554/eLife.42404.008
DOI:
10.7554/eLife.42404.009
DOI:
10.7554/eLife.42404.010
DOI:
10.7554/eLife.42404.011
DOI:
10.7554/eLife.42404.012
DOI:
10.7554/eLife.42404.014
DOI:
10.7554/eLife.42404.015
DOI:
10.7554/eLife.42404.016
DOI:
10.7554/eLife.42404.017
DOI:
10.7554/eLife.42404.018
DOI:
10.7554/eLife.42404.019
DOI:
10.7554/eLife.42404.023
DOI:
10.7554/eLife.42404.024
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2019
detail.hit.zdb_id:
2687154-3