In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-10-29)
Abstract:
When facing microbes, animals engage in behaviors that lower the impact of the infection. We previously demonstrated that internal sensing of bacterial peptidoglycan reduces Drosophila female oviposition via NF-κB pathway activation in some neurons (Kurz et al., 2017). Although we showed that the neuromodulator octopamine is implicated, the identity of the involved neurons, as well as the physiological mechanism blocking egg-laying, remained unknown. In this study, we identified few ventral nerve cord and brain octopaminergic neurons expressing an NF-κB pathway component. We functionally demonstrated that NF-κB pathway activation in the brain, but not in the ventral nerve cord octopaminergic neurons, triggers an egg-laying drop in response to infection. Furthermore, we demonstrated via calcium imaging that the activity of these neurons can be directly modulated by peptidoglycan and that these cells do not control other octopamine-dependent behaviors such as female receptivity. This study shows that by sensing peptidoglycan and hence activating NF-κB cascade, a couple of brain neurons modulate a specific octopamine-dependent behavior to adapt female physiology status to their infectious state.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.50559.001
DOI:
10.7554/eLife.50559.002
DOI:
10.7554/eLife.50559.003
DOI:
10.7554/eLife.50559.004
DOI:
10.7554/eLife.50559.071
DOI:
10.7554/eLife.50559.005
DOI:
10.7554/eLife.50559.006
DOI:
10.7554/eLife.50559.007
DOI:
10.7554/eLife.50559.008
DOI:
10.7554/eLife.50559.009
DOI:
10.7554/eLife.50559.010
DOI:
10.7554/eLife.50559.011
DOI:
10.7554/eLife.50559.012
DOI:
10.7554/eLife.50559.072
DOI:
10.7554/eLife.50559.013
DOI:
10.7554/eLife.50559.014
DOI:
10.7554/eLife.50559.015
DOI:
10.7554/eLife.50559.016
DOI:
10.7554/eLife.50559.017
DOI:
10.7554/eLife.50559.018
DOI:
10.7554/eLife.50559.019
DOI:
10.7554/eLife.50559.020
DOI:
10.7554/eLife.50559.021
DOI:
10.7554/eLife.50559.022
DOI:
10.7554/eLife.50559.024
DOI:
10.7554/eLife.50559.025
DOI:
10.7554/eLife.50559.026
DOI:
10.7554/eLife.50559.027
DOI:
10.7554/eLife.50559.023
DOI:
10.7554/eLife.50559.028
DOI:
10.7554/eLife.50559.029
DOI:
10.7554/eLife.50559.032
DOI:
10.7554/eLife.50559.030
DOI:
10.7554/eLife.50559.031
DOI:
10.7554/eLife.50559.033
DOI:
10.7554/eLife.50559.034
DOI:
10.7554/eLife.50559.035
DOI:
10.7554/eLife.50559.036
DOI:
10.7554/eLife.50559.039
DOI:
10.7554/eLife.50559.037
DOI:
10.7554/eLife.50559.038
DOI:
10.7554/eLife.50559.040
DOI:
10.7554/eLife.50559.041
DOI:
10.7554/eLife.50559.073
DOI:
10.7554/eLife.50559.047
DOI:
10.7554/eLife.50559.048
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2019
detail.hit.zdb_id:
2687154-3
