In:
PeerJ, PeerJ, Vol. 6 ( 2018-03-06), p. e4466-
Kurzfassung:
RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes ( rs2028299 ) was associated with editing in ARPIN . Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process.
Materialart:
Online-Ressource
ISSN:
2167-8359
DOI:
10.7717/peerj.4466/fig-1
DOI:
10.7717/peerj.4466/fig-2
DOI:
10.7717/peerj.4466/fig-3
DOI:
10.7717/peerj.4466/table-1
DOI:
10.7717/peerj.4466/table-2
DOI:
10.7717/peerj.4466/table-3
DOI:
10.7717/peerj.4466/supp-1
DOI:
10.7717/peerj.4466/supp-2
DOI:
10.7717/peerj.4466/supp-3
DOI:
10.7717/peerj.4466/supp-4
Sprache:
Englisch
Verlag:
PeerJ
Publikationsdatum:
2018
ZDB Id:
2703241-3