Format:
Online-Ressource
ISSN:
1521-3765
Content:
Abstract: The first total synthesis of glycocin F, a uniquely diglycosylated antimicrobial peptide bearing a rare S‐linked N‐acetylglucosamine (GlcNAc) moiety in addition to an O‐linked GlcNAc, has been accomplished using a native chemical ligation strategy. The synthetic and naturally occurring peptides were compared by HPLC, mass spectrometry, NMR and CD spectroscopy, and their stability towards chymotrypsin digestion and antimicrobial activity were measured. This is the first comprehensive structural and functional comparison of a naturally occurring glycocin with an active synthetic analogue.
In:
volume:21
In:
number:9
In:
year:2015
In:
pages:3556-3561
In:
extent:6
In:
Chemistry - a European journal, Weinheim : Wiley-VCH, 1995-, 21, Heft 9 (2015), 3556-3561 (gesamt 6), 1521-3765
Language:
English
DOI:
10.1002/chem.201405692
URN:
urn:nbn:de:101:1-2022121608211668030807
URL:
https://doi.org/10.1002/chem.201405692
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2022121608211668030807
URL:
https://d-nb.info/1275731457/34
URL:
https://doi.org/10.1002/chem.201405692