Umfang:
Online-Ressource
ISSN:
1521-3757
Inhalt:
Abstract: Reported herein are two imidazole‐based small molecules, termed neurodazine (Nz) and neurodazole (Nzl), which induce neuronal differentiation of pluripotent P19 cells. Their ability to induce neurogenesis of P19 cells is comparable to that of retinoic acid. However, Nz and Nzl were found to be more selective neurogenesis inducers than retinoic acid owing to their unique ability to suppress astrocyte differentiation of P19 cells. Our results also show that Nz and Nzl promote production of physiologically active neurons because P19‐cell‐derived neurons induced by these substances have functional glutamate responsiveness. The present study suggests that Nz and Nzl could serve as important chemical tools to induce formation of specific populations of neuronal cell types from pluripotent cells.
In:
volume:126
In:
number:35
In:
year:2014
In:
pages:9425-9428
In:
extent:4
In:
Angewandte Chemie, Weinheim : Wiley-VCH, 1887-, 126, Heft 35 (2014), 9425-9428 (gesamt 4), 1521-3757
Sprache:
Englisch
DOI:
10.1002/ange.201404871
URN:
urn:nbn:de:101:1-2023010704511781237545
URL:
https://doi.org/10.1002/ange.201404871
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023010704511781237545
URL:
https://d-nb.info/1277431779/34
URL:
https://doi.org/10.1002/ange.201404871