Format:
Online-Ressource
ISSN:
2192-2659
Content:
Cancer is a complex disease that usually requires several treatment modalities. A multifunctional nanotherapeutic system is designed, incorporating small interfering RNA (siRNA) and gold nanorods (Au NRs) for photothermal therapy. Surface‐engineered Au NRs with polyethylenimine are synthesized using a layer‐by‐layer assembly and siRNA is absorbed on the surface. The siRNA is efficiently delivered into breast cancer cells, resulting in subsequent gene silencing. Cells are then irradiated with near‐infrared (NIR) light, causing heat‐induced anticancer activity. The combination of gene silencing and photothermal therapy results in effective inhibition of cell proliferation.
In:
volume:3
In:
number:10
In:
year:2014
In:
pages:1629-1637
In:
extent:9
In:
Advanced healthcare materials, Weinheim : Wiley-VCH, [2012]-, 3, Heft 10 (2014), 1629-1637 (gesamt 9), 2192-2659
Language:
English
DOI:
10.1002/adhm.201400103
URN:
urn:nbn:de:101:1-2023010906011678430689
URL:
https://doi.org/10.1002/adhm.201400103
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023010906011678430689
URL:
https://d-nb.info/1277539685/34
URL:
https://doi.org/10.1002/adhm.201400103