Format:
Online-Ressource
ISSN:
1860-7187
Content:
Abstract: Recent advances in the methodologies employed to deeply analyse the complexity of transcriptomes have unveiled the existence of a new class of transcripts, long noncoding RNAs (lncRNAs). A significant amount of effort has been dedicated to the study of lncRNAs, and a large body of evidence now exists indicating their relevant role in different regulatory steps of gene expression. Given the role of epigenetics in disease development and progression, this Minireview focuses on lncRNAs involved in epigenetic control and provides an overview of the mechanisms used to guide epigenetic‐modifying complexes to adjacent (cis‐acting) or independent (trans‐acting) genomic loci. Furthermore, it describes the activities of these transcripts in controlling the formation and spreading of heterochromatin domains. Just as other RNA molecules have found therapeutic application, though much remains to be elucidated about the structure and function of these lncRNAs, they too could hold potential as biomarkers, targets, and therapeutic agents.
In:
volume:9
In:
number:3
In:
year:2014
In:
pages:505-510
In:
extent:6
In:
ChemMedChem, Weinheim : Wiley-VCH, [2006]-, 9, Heft 3 (2014), 505-510 (gesamt 6), 1860-7187
Language:
English
DOI:
10.1002/cmdc.201300569
URN:
urn:nbn:de:101:1-2023011907315405252099
URL:
https://doi.org/10.1002/cmdc.201300569
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023011907315405252099
URL:
https://d-nb.info/1278569650/34
URL:
https://doi.org/10.1002/cmdc.201300569