Umfang:
Online-Ressource
ISSN:
1099-0690
Inhalt:
Abstract: Enantiopure β‐nitro alcohols are key chiral building blocks for the synthesis of bioactive pharmaceutical ingredients. The preparation of these target compounds in optically pure form has been the focus of much research and there has been an emergence of biocatalytic protocols in the past decade. For the first time, these biotransformations are the focus of this review. Herein, we describe two principal biocatalytic approaches to the Henry (nitroaldol) reaction. The first method is a direct enzyme‐catalysed carbon–carbon bond formation resulting in either an enantio‐enriched or enantiopure β‐nitro alcohol. The second approach describes the Henry reaction without stereocontrol followed by a biocatalytic resolution to yield the enantiopure β‐nitro alcohol.
In:
volume:2012
In:
number:16
In:
year:2012
In:
pages:3059-3067
In:
extent:9
In:
European journal of organic chemistry, Weinheim : Wiley-VCH Verl., 1998-, 2012, Heft 16 (2012), 3059-3067 (gesamt 9), 1099-0690
Sprache:
Englisch
DOI:
10.1002/ejoc.201101840
URN:
urn:nbn:de:101:1-2023022407342513204667
URL:
https://doi.org/10.1002/ejoc.201101840
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023022407342513204667
URL:
https://d-nb.info/1281843210/34
URL:
https://doi.org/10.1002/ejoc.201101840