Format:
Online-Ressource
ISSN:
1521-3935
Content:
Abstract: Multi‐arm poly (THF)‐b‐polyglycerol linear‐hyperbranched copolymers consisting of a linear hydrophobic poly (THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the micelle properties of the copolymers on the number of arms. The critical micelle concentration (CMC) first decreased and then increased with increasing numbers of arms showing a minimum CMC at an arm number of 2. A minimum CMC was difficult to obtain using multi‐arm block copolymers composed of linear polymers with the small number of arms investigated in this study. DLS showed that the 4‐arm poly (THF)‐b‐polyglycerol copolymer had a micelle size of approximately 83 nm under aqueous conditions, and the micelle size of the copolymers with different numbers of arms was similar. Unimolecular micelles could eventually be obtained using this system by increasing the number of arms, they are considered an ideal drug delivery carrier due to the concentration‐independent stability in the blood stream.
In:
volume:210
In:
number:20
In:
year:2009
In:
pages:1734-1738
In:
extent:5
In:
Macromolecular chemistry and physics, Weinheim : Wiley-VCH, 1947-, 210, Heft 20 (2009), 1734-1738 (gesamt 5), 1521-3935
Language:
English
DOI:
10.1002/macp.200900217
URN:
urn:nbn:de:101:1-2023042010052398462972
URL:
https://doi.org/10.1002/macp.200900217
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023042010052398462972
URL:
https://d-nb.info/1286718740/34
URL:
https://doi.org/10.1002/macp.200900217