Format:
Online-Ressource
ISSN:
1521-3765
Content:
Abstract: A detailed study on the solid‐phase synthesis of lipidated peptides of the Ras family employing the Ellman sulfonamide linker is reported. Using the C‐terminal N‐Ras sequence, critical issues such as lipidated amino acid resin loading, peptide elongation in the presence of labile groups and optimized conditions for release of the peptides were investigated. A versatile methodology for the synthesis of peptides with diverse lipid motifs and C‐terminal methyl esters has accordingly been established.
In:
volume:16
In:
number:31
In:
year:2010
In:
pages:9585-9591
In:
extent:7
In:
Chemistry - a European journal, Weinheim : Wiley-VCH, 1995-, 16, Heft 31 (2010), 9585-9591 (gesamt 7), 1521-3765
Language:
English
DOI:
10.1002/chem.201001642
URN:
urn:nbn:de:101:1-2023042706545665231979
URL:
https://doi.org/10.1002/chem.201001642
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023042706545665231979
URL:
https://d-nb.info/1287142958/34
URL:
https://doi.org/10.1002/chem.201001642