Format:
Online-Ressource
ISSN:
2191-0251
Content:
Objectives: Elevated free T3 (FT3) is an important feature for the early diagnosis of several diseases among which Grave’s disease or Allan-Hernon-Dudley syndrome. However, there is a lack of age-adapted reference intervals for plasma thyroid hormones in children. We conducted a study to define reference values of peripheral FT3 in children using a commonly used automated immunoassay. Methods: All thyroid function test (TFT) results from our lab collected during 9 months were extracted anonymously, and reference intervals establishment followed recommendations validated by International Federation of Clinical Chemistry (IFCC). Results: We defined five reference intervals covering the whole pediatric period. Overall, 26.1% of peripheral FT3 measured in children with normal TSH are out of the adult reference range, and 22.2% are upper it leading to misinterpretation. In a 9-month old patient with severe neurodevelopmental disorders, a pathological elevated FT3 has been securely interpreted using the newly established interval. Conclusions: The study highlights the poor relevance of adult intervals in pediatric cares, as it confirms that plasmatic FT3 is higher during the whole pediatric period. This work reports useful age-adapted reference intervals for free T3 in pediatrics using a widely used electrochemiluminescent Immunoassay (ECLIA) kit.
In:
volume:36
In:
number:5
In:
year:2023
In:
pages:478-483
In:
extent:06
In:
The journal of pediatric endocrinology and metabolism, Berlin [u.a.] : de Gruyter, 1985-, 36, Heft 5 (2023), 478-483 (gesamt 06), 2191-0251
Language:
English
DOI:
10.1515/jpem-2022-0330
URN:
urn:nbn:de:101:1-2023050214084001264968
URL:
https://doi.org/10.1515/jpem-2022-0330
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023050214084001264968
URL:
https://d-nb.info/1287712266/34