Format:
Online-Ressource
ISSN:
2193-5815
Content:
Abstract: Quaternary carbons are useful motifs in chemical synthesis but can be challenging to prepare using many chemical methods. Here, we report a stereoselective synthesis of β‐quaternary lactams using flavin‐dependent ‘ene’‐reductases via a 5‐exo‐trig radical cyclization. The products are formed in moderate to good levels of enantioselectivity using an ‘ene’‐reductase variant from Zymomonas mobilis. This method highlights the opportunity for biocatalysis to form quaternary centers using non‐natural reactions.
In:
day:24
In:
month:07
In:
year:2023
In:
extent:4
In:
Asian journal of organic chemistry, Weinheim : Wiley-VCH, [2012]-, (24.07.2023) (gesamt 4), 2193-5815
Language:
English
DOI:
10.1002/ajoc.202300274
URN:
urn:nbn:de:101:1-2023072415293701715956
URL:
https://doi.org/10.1002/ajoc.202300274
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023072415293701715956
URL:
https://d-nb.info/1297185692/34
URL:
https://doi.org/10.1002/ajoc.202300274