Format:
Online-Ressource
ISSN:
1469-3178
Content:
Nuclear components are functionally linked with the dynamic temporal and spatial compartmentalization, sorting and integration of regulatory information to facilitate its selective use. For example, the subnuclear targeting of transcription factors to punctate sites in the interphase nucleus mechanistically couples chromatin remodelling and the execution of signalling cascades that mediate gene expression with the combinatorial assembly of the regulatory machinery for biological control. In addition, a mitotic cycle of selective partitioning and sequential restoration of the transcriptional machinery provides a basis for the reassembly of regulatory complexes to render progeny cells competent for phenotypic gene expression. When this intranuclear targeting and localization of regulatory proteins is compromised, diseases, such as cancer, can occur. A detailed understanding of this process will provide further options for diagnosis and treatment.
In:
volume:6
In:
number:2
In:
year:2005
In:
pages:128-133
In:
extent:6
In:
European Molecular Biology Organization, EMBO reports, Heidelberg : EMBO Press, [200]-, 6, Heft 2 (2005), 128-133 (gesamt 6), 1469-3178
Language:
English
DOI:
10.1038/sj.embor.7400337
URN:
urn:nbn:de:101:1-2023090806553562023074
URL:
https://doi.org/10.1038/sj.embor.7400337
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023090806553562023074
URL:
https://d-nb.info/1301859354/34
URL:
https://doi.org/10.1038/sj.embor.7400337