Format:
Online-Ressource
ISSN:
1678-4227
Content:
Abstract: Astrocytes are the most abundant cell subtypes in the central nervous system. Previous studies believed that astrocytes are supporting cells in the brain, which only provide nutrients for neurons. However, recent studies have found that astrocytes have more crucial and complex functions in the brain, such as neurogenesis, phagocytosis, and ischemic tolerance. After an ischemic stroke, the activated astrocytes can exert neuroprotective or neurotoxic effects through a variety of pathways. In this review, we will discuss the neuroprotective mechanisms of astrocytes in cerebral ischemia, and mainly focus on reactive astrocytosis or glial scar, neurogenesis, phagocytosis, and cerebral ischemic tolerance, for providing new strategies for the clinical treatment of stroke.
In:
volume:81
In:
number:08
In:
year:2023
In:
pages:748-755
In:
Arquivos de neuro-psiquiatria, São Paulo : Academia Brasileira de Neurologia, [1943]-, 81, Heft 08 (2023), 748-755, 1678-4227
Language:
English
DOI:
10.1055/s-0043-1770352
URN:
urn:nbn:de:101:1-2023101212042619018448
URL:
https://doi.org/10.1055/s-0043-1770352
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101212042619018448
URL:
https://d-nb.info/1305835891/34