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The 6‐OH Group of d ‐Inositol 1‐Phosphate Serves as an H‐Bond Donor in the Catalytic Hydrolysis of the Phosphate Ester by Inositol Monophosphatase (2000)

Miller, David J. [Verfasser] ; Beaton, Martin W. [Verfasser] ; Wilkie, John [Verfasser] ; [et al.]

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UID:

(DE-101)1309779007

Format: Online-Ressource

ISSN: 1439-7633

Content: A pivotal role is played by inositol monophosphatase in the biosynthesis of secondary messengers. Several d‐myo‐inositol derivatives have been synthesised and their activities with the enzyme have been studied. Evidence has been found that the 6‐hydroxy group of d‐inositol 1‐phosphate is an essential hydrogen‐bond donor during the hydrolysis reaction.

In: volume:1

In: number:4

In: year:2000

In: pages:262-271

In: extent:10

In: ChemBioChem, Weinheim : Wiley-VCH, [2000]-, 1, Heft 4 (2000), 262-271 (gesamt 10), 1439-7633

Language: English

DOI: 10.1002/1439-7633(20001117)1:4〈262::AID-CBIC262〉3.0.CO;2-#

URN: urn:nbn:de:101:1-2023111406341244690409

URL: https://doi.org/10.1002/1439-7633(20001117)1:4〈262::AID-CBIC262〉3.0.CO;2-#

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023111406341244690409

URL: https://d-nb.info/1309779007/34