Format:
Online-Ressource
ISSN:
1521-4141
Content:
Abstract: Blimp‐1 (B lymphocyte‐induced maturation protein 1) is strongly expressed during the late stages of B cell differentiation to immunoglobulin‐secreting plasma cells. Overexpression of Blimp‐1 in B lymphoma cells has been reported to induce either growth arrest and cell death or Ig secretion and terminal differentiation, depending on the developmental stage of the recipient lymphomas. By using a retroviral expression system we show that Blimp‐1‐transduced immature WEHI 231 murine B lymphoma cells produce J chain, increased levels of the secretory form of μ heavy chain mRNA and secrete IgM for a short period of time. Concomitantly, they exhibit altered ratios of c‐myc/mad4 mRNA levels, a reduction in the expression of the anti‐apoptotic bcl‐2 family member A1 and a distinct growth disadvantage, followed by cell death. Reintroduction of A1 by retroviral transduction greatly extends the life span of Blimp‐1‐expressing WEHI 231 cells which continue to secrete IgM. These data suggest that levels of A1 may determine the checkpoint between death and survival of Blimp‐1‐expressing B cells at different stages of differentiation.
In:
volume:29
In:
number:9
In:
year:2006
In:
pages:2988-2998
In:
extent:11
In:
European journal of immunology, Weinheim : Wiley-VCH, 1971-, 29, Heft 9 (2006), 2988-2998 (gesamt 11), 1521-4141
Language:
English
DOI:
10.1002/(SICI)1521-4141(199909)29:09〈2988::AID-IMMU2988〉3.0.CO;2-T
URN:
urn:nbn:de:101:1-2023113006342306264679
URL:
https://doi.org/10.1002/(SICI)1521-4141(199909)29:09〈2988::AID-IMMU2988〉3.0.CO;2-T
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023113006342306264679
URL:
https://d-nb.info/1311692533/34
URL:
https://doi.org/10.1002/(SICI)1521-4141(199909)29:09〈2988::AID-IMMU2988〉3.0.CO;2-T