Format:
Online-Ressource
ISSN:
1460-2075
Content:
oriLyt, the lytic origin of DNA replication of Epstein‐Barr virus (EBV), ensures viral DNA amplification during the productive or lytic phase of the virus' life cycle. To understand the contribution of cis‐ and transacting elements involved in DNA replication of oriLyt, a detailed mutational analysis was undertaken which defined BZLF1, a viral transcriptional activator, as an essential replication factor. The BZLF1 protein belongs to the extended fos/jun family of transcription factors and binds to specific BZLF1 binding motifs within oriLyt, as well as to consensus AP‐1 sites. Recombinant, chimeric transcription factors identified the transcriptional activation domain of BZLF1 as being necessary to mediate DNA replication, a function which could not be substituted by any other transcription factor tested, including jun, E2, myc or VP16.
In:
volume:12
In:
number:10
In:
year:1993
In:
pages:3921-3929
In:
extent:9
In:
European Molecular Biology Organization, The EMBO journal, Heidelberg : EMBO Press, 1982-, 12, Heft 10 (1993), 3921-3929 (gesamt 9), 1460-2075
Language:
English
DOI:
10.1002/j.1460-2075.1993.tb06070.x
URN:
urn:nbn:de:101:1-2024011904551408389750
URL:
https://doi.org/10.1002/j.1460-2075.1993.tb06070.x
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2024011904551408389750
URL:
https://d-nb.info/1316443833/34
URL:
https://doi.org/10.1002/j.1460-2075.1993.tb06070.x