Format:
Online-Ressource
ISSN:
1613-4133
Content:
Scope: Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC. Methods and Results: We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer. Conclusion: Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.
In:
day:20
In:
month:05
In:
year:2024
In:
extent:17
In:
Molecular nutrition & food research, Weinheim : Wiley-VCH, [2004]-, (20.05.2024) (gesamt 17), 1613-4133
Language:
English
DOI:
10.1002/mnfr.202300793
URN:
urn:nbn:de:101:1-2405201415373.955410566052
URL:
https://doi.org/10.1002/mnfr.202300793
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2405201415373.955410566052
URL:
https://d-nb.info/133007095X/34
URL:
https://doi.org/10.1002/mnfr.202300793
