Umfang:
Online-Ressource
ISSN:
1437-4315
Inhalt:
Abstract: Human carbonic anhydrase (hCA) VII is a cytosolic enzyme with high carbon dioxide hydration activity. Recently, S-glutathionylation of two cysteine residues from the enzyme was revealed, suggesting a new role as oxygen radical scavenger. We analyzed the effect of native and tetramutated hCA VII (all cysteines mutated into serines) in a eukaryotic system by stressing cells with an oxidant agent. Results clearly show that native hCA VII can protect cells from oxidative damage by preventing the apoptosis cascade and that cysteines play a leading role in this process. Our findings definitively confirm hCA VII protective role toward oxidative insult.
In:
volume:394
In:
number:10
In:
year:2013
In:
pages:1343-1348
In:
Biological chemistry, Berlin [u.a.] : de Gruyter, 1996-, 394, Heft 10 (2013), 1343-1348, 1437-4315
Sprache:
Englisch
DOI:
10.1515/hsz-2013-0204
URN:
urn:nbn:de:101:1-2408051732235.984799424508
URL:
https://doi.org/10.1515/hsz-2013-0204
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2408051732235.984799424508
URL:
https://d-nb.info/133794713X/34
