Format:
Online-Ressource
ISSN:
2041-4889
Content:
Adaptation of wild-type p53 expressing UKF-NB-3 cancer cells to the murine double minute 2 inhibitor nutlin-3 causes de novo p53 mutations at high frequency (13/20) and multi-drug resistance. Here, we show that the same cells respond very differently when adapted to RITA, a drug that, like nutlin-3, also disrupts the p53/Mdm2 interaction. All of the 11 UKF-NB-3 sub-lines adapted to RITA that we established retained functional wild-type p53 although RITA induced a substantial p53 response. Moreover, all RITA-adapted cell lines remained sensitive to nutlin-3, whereas only five out of 10 nutlin-3-adapted cell lines retained their sensitivity to RITA. ...
In:
Cell death & disease, London [u.a.] : Nature Publishing Group, 2010-, Band 3, Heft 294 (2012), 2041-4889
In:
volume:3
In:
year:2012
In:
number:294
In:
extent:8
Language:
English
DOI:
10.1038/cddis.2012.35
URN:
urn:nbn:de:hebis:30:3-253305