Format:
Online-Ressource
ISSN:
1932-6203
Content:
Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of the pan-aurora kinase inhibitor tozasertib (VX680, MK-0457) and the aurora kinase inhibitor alisertib (MLN8237) that shows some specificity for aurora kinase A over aurora kinase B in a panel of neuroblastoma cell lines with acquired drug resistance. Both compounds displayed anti-neuroblastoma activity in the nanomolar range. ...
In:
PLOS ONE, San Francisco, California, US : PLOS, 2006-, Band 9, Heft 9 (2014), 1932-6203
In:
volume:9
In:
year:2014
In:
number:9
In:
extent:9
Language:
English
DOI:
10.1371/journal.pone.0108758
URN:
urn:nbn:de:hebis:30:3-351010