Format:
1 online resource (918 pages)
Edition:
1st ed.
ISBN:
9781118498170
Content:
Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used
Content:
Intro -- CHEMICAL SYNTHESIS OF NUCLEOSIDE ANALOGUES -- CONTENTS -- Contributors -- Foreword -- Preface -- 1 Biocatalytic Methodologies for Selective Modified Nucleosides -- 1. INTRODUCTION -- 2. TRANSFORMATIONS ON THE SUGAR MOIETY -- 2.1. Enzymatic Acylation/Hydrolysis -- 2.2. Resolutions of Racemic Mixtures -- 2.3. Asymmetrizations and Desymmetrizations -- 2.4. Separation of Mixtures -- 2.5. Preparation of Nucleoside Derivatives -- 2.6. Alkoxycarbonylations and Hydrolysis -- 3. BIOTRANSFORMATIONS THAT MODIFY THE BASE -- 4. MOLECULAR MODELING -- 5. CONCLUDING REMARKS -- ABBREVIATIONS -- REFERENCES -- 2 Nucleosides Modified at the Base Moiety -- 1. INTRODUCTION -- 2. RUTHENIUM-CATALYZED C-H BOND ACTIVATION FOR NUCLEOSIDE SYNTHESES -- 3. METALLO-CATALYZED SYNTHESES AND MODIFICATIONS OF TRIAZOLO NUCLEOSIDES -- 3.1. Pd(0)-Catalyzed Functionalization of a 1,2,4-Triazole Ring -- 3.2. Copper/Ruthenium-Catalyzed Azide-Alkyne Cycloadditions to a 1,2,3-Triazole Ring -- 4. SELECTED NUCLEOBASE-MODIFIED NUCLEOSIDES -- 4.1. Ribavirin Analogues -- 4.2. Thio or Seleno Derivatives -- 4.3. Fleximers -- 4.4. Selected Modified Uracil Analogues -- 4.5. Cyclonucleosides -- 4.6. Miscellaneous 5-Substituted Nucleosides -- 5. CONCLUDING REMARKS -- ABBREVIATIONS -- REFERENCES -- 3 Chemical Synthesis of Acyclic Nucleosides -- 1. INTRODUCTION -- 2. SYNTHESIS OF ACYCLIC NUCLEOSIDES -- 2.1. Synthesis of Acyclic Nucleosides with Acyclovir Side-Chain Analogues (Type I) -- 2.2. Synthesis of Acyclic Nucleosides with Ganciclovir Side-Chain Analogues (Type II) -- 2.3. Synthesis of Acyclic Nucleosides with Adefovir Side-Chain Analogues (Type III) -- 2.4. Synthesis of Acyclic Nucleosides with Cidofovir Side-Chain Analogues (Type IV) -- 2.5. Synthesis of Acyclic ucleosides with Buciclovir Side-Chain Analogues (Type V) -- 2.6. New Progress -- 3. OUTLOOK -- ABBREVIATIONS -- REFERENCES.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9781118007518
Additional Edition:
Erscheint auch als Druck-Ausgabe Chemical synthesis of nucleoside analogues Hoboken, N.J : Wiley, 2013 9781118007518
Language:
English
Subjects:
Chemistry/Pharmacy
Keywords:
Nucleosidanaloga
;
Chemische Synthese
URL:
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