Format:
1 online resource (402 pages)
Edition:
2nd ed.
ISBN:
9781118410905
Content:
Managing patients with thrombotic vascular disease is complex and challenging: Ischemic vascular disease remains a complicated interplay of atherosclerosis and thrombosis-even with the evolution in our understanding of the pathobiology of thrombosis. There has been tremendous growth in therapeutic options which are quickly finding their place in daily practice, including a remarkable expansion in the number of intravenous and oral antithrombotic agents and new antiplatelet agents Now more than ever, all cardiologists, hematologists, and specialists in vascular medicine, as well as other professionals, such as hospital pharmacists, who deal with prognosis and intervention in preventing thrombosis, need a resource that distills current knowledge of this important subject. Written and edited by today's leading international, Therapeutic Advances in Thrombosis, 2e provides physicians with the very latest in medical and surgical advances in antithrombotic therapies. With this comprehensively updated edition you get: Coverage of virtually all aspects of venous and arterial thrombotic disease and the corresponding therapies Strategies to manage specific clinical conditions and how to tailor treatment to individual patient needs Updated chapters covering thrombolysis in ST-elevated myocardial infarctions; thrombosis in patients with diabetes, pregnancy, and renal dysfunction Special emphasis on the pharmacology of novel anticoagulants and their practical use in venous thromboembolism and atrial fibrillation. Plus, all chapters fully explore clinical trial designs and outcomes for particular treatment therapies, as well as contain the relevant ACC/AHA/ESC guidelines, so you can confidently apply what you learn.
Content:
Intro -- Title page -- Copyright page -- Contents -- Contributors -- Foreword -- Preface -- CHAPTER 1: Arterial thrombosis: a brief overview -- Introduction -- Pathogenesis of arterial thrombosis -- Platelets -- Coagulation system -- Effects of the severity of vessel wall damage and local geometry on the thrombotic response to atherosclerosis -- Inflammation in arterial thrombosis -- Platelets as circulating commodities in vascular disease -- Summary -- Acknowledgements -- References -- CHAPTER 2: Aspirin -- Introduction -- Mechanism of action of aspirin in inhibiting platelet function -- Pharmacokinetics -- Pharmacodynamics -- Effects on TXA2 and PGI2 biosynthesis -- Effects of aspirin not related to COX-1 inactivation -- Drug interactions -- Interindividual variability in response to low-dose aspirin -- Efficacy and safety of low-dose aspirin -- Prevention and treatment of atherothrombosis in high-risk patients -- Patients at intermediate risk of vascular complications -- Low-risk subjects -- Summary -- References -- CHAPTER 3: Platelet ADP P2Y12 inhibitors: thienopyridines -- Introduction -- The ADP receptor -- Thienopyridine ADP P2Y12 receptor antagonists -- Ticlopidine -- Clopidogrel -- Mechanism of action -- Pharmacodynamics -- Clinical uses -- Dosing and platelet responsiveness -- Pharmacogenomics -- Drug interactions -- Stent thrombosis and clopidogrel duration -- Perioperative bleeding and clopidogrel timing -- Prasugrel -- Mechanism of action -- Platelet responsiveness and prasugrel dosing -- Clinical studies -- Summary -- References -- CHAPTER 4: Platelet ADP P2Y12 inhibitors: nonthienopyridines -- Introduction -- Ticagrelor -- Mechanism of action -- Pharmacokinetics -- Clinical trials -- Cangrelor -- Pharmacodynamics -- Clinical studies -- Future agents -- Elinogrel -- BX 667 -- Summary -- References.
Note:
Description based on publisher supplied metadata and other sources
Additional Edition:
9781405196253
Additional Edition:
Erscheint auch als Druck-Ausgabe 9781405196253
Language:
English
