Format:
36
ISSN:
1097-4180
Content:
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the transcription factor BATF. This signature, combined with gene expression profiling and TCR fate mapping, identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with nonlymphoid T follicular helper-like (Tfh-like) cells, and induction of a Tfh-like differentiation program in naive human Treg cells partially recapitulated tissue Treg regenerative characteristics, including wound healing potential. Human BATF+CCR8+ Treg cells from healthy tissue share features with tumor-resident Treg cells, highlighting the importance of understanding the context-specific functions of these cells.
Note:
Gesehen am 27.05.2021
In:
Immunity, [Cambridge, Mass.] : Cell Press, 1994, 54(2021,4) Seite 702-720, e1-e17, 36 Seiten, 1097-4180
In:
volume:54
In:
year:2021
In:
number:4
In:
month:04
In:
extent:36
Language:
English
DOI:
10.1016/j.immuni.2021.03.007
URL:
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