Format:
18
ISSN:
1422-0067
Content:
Abstract: miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings. Keywords: miR-149-5p; cancer; biomarker; expression; ncRNAs
In:
International journal of molecular sciences, Basel : Molecular Diversity Preservation International, 2000, 23(2022), 1, Artikel-ID 415, 1422-0067
In:
volume:23
In:
year:2022
In:
number:1
In:
elocationid:415
In:
extent:18
Language:
English
DOI:
10.3390/ijms23010415