Umfang:
1 online resource (248 pages)
ISBN:
9780323906654
Inhalt:
Front Cover -- Feedback Control for Personalized Medicine -- Copyright -- Contents -- Contributors -- About the editor -- Preface -- Acknowledgments -- 1 Closing the loop in personalized medicine -- References -- 2 Optimal control strategies to tailor antivirals for acute infectious diseases in the host: a study case of COVID-19 -- 2.1 Introduction -- 2.1.1 Notation -- 2.2 Review of the target cell limited model for in-host infection -- 2.3 Equilibrium characterization and stability -- 2.3.1 Asymptotic stability of the equilibrium sets -- 2.3.2 Stability theory -- 2.3.3 Attractivity of set Xsst -- 2.3.4 Local ε-δ stability of Xsst -- 2.3.5 Asymptotic stability of Xsst -- 2.3.6 U∞ as a function of initial conditions -- 2.3.7 Simulation example -- 2.4 Inclusion of PK and PD of antiviral treatment -- 2.4.1 Impulsive scheme -- 2.4.2 Simulation example -- 2.5 Control strategies to tailor therapies -- 2.5.1 First control objective: maximizing the final value of the uninfected cells -- 2.5.2 Second control objective: minimizing the virus peak -- 2.6 Simulation results -- 2.6.1 Strong long-term treatment. Virus rebound -- 2.6.2 Soft long-term treatment -- 2.6.3 Quasioptimal single interval treatment -- 2.6.4 Short-term treatment -- 2.6.5 Two-step treatment, lowering the peak of V -- 2.7 Conclusions and future works -- References -- 3 Input-output approaches for personalized drug dosing of antibiotics -- 3.1 Introduction -- 3.2 Population pharmacokinetic model -- 3.2.1 State-space representation -- 3.2.2 System analysis -- 3.2.3 Case study: model of meropenem -- 3.3 Individualized drug dosing -- 3.3.1 Input-output analysis -- 3.3.2 Input-output formula for drug dosing -- 3.3.3 ``Worst-case'' analysis -- 3.3.4 PTA analysis -- 3.3.5 Drawbacks and advantages of the I/O approach -- 3.4 State estimation and feedback control law -- 3.5 Conclusion.
Anmerkung:
Description based on publisher supplied metadata and other sources
Weitere Ausg.:
9780323901710
Weitere Ausg.:
Erscheint auch als Druck-Ausgabe 9780323901710
Sprache:
Englisch
