Format:
9
ISSN:
1875-9777
Content:
Human colon cancer harbors a small subfraction of tumor-initiating cells (TICs) that is assumed to be a functionally homogeneous stem-cell-like population driving tumor maintenance and metastasis formation. We found unexpected cellular heterogeneity within the TIC compartment, which contains three types of TICs. Extensively self-renewing long-term TICs (LT-TICs) maintained tumor formation in serial xenotransplants. Tumor transient amplifying cells (T-TACs) with limited or no self-renewal capacity contributed to tumor formation only in primary mice. Rare delayed contributing TICs (DC-TICs) were exclusively active in secondary or tertiary mice. Bone marrow was identified as an important reservoir of LT-TICs. Metastasis formation was almost exclusively driven by self-renewing LT-TICs. Our results demonstrate that tumor initiation, self-renewal, and metastasis formation are limited to particular subpopulations of TICs in primary human colon cancer. We identify LT-TICs as a quantifiable target for therapies aimed toward eradication of self-renewing tumorigenic and metastatic colon cancer cells.
Note:
Gesehen am 10.06.2022
In:
Cell stem cell, Amsterdam [u.a.] : Elsevier, 2007, 9(2011), 4, Seite 357-365, 1875-9777
In:
volume:9
In:
year:2011
In:
number:4
In:
pages:357-365
In:
extent:9
Language:
English
DOI:
10.1016/j.stem.2011.08.010
URL:
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