Format:
1 Online-Ressource (34 p)
Content:
Background: The objective of this study was to describe 12-month mortality following COVID-19 compared with a reference population with no history of COVID-19.Methods: Retrospective nationwide cohort study using electronic health care data on cases (n= 66,287 COVID-19 patients) and controls (n=254,969) with linkage to SARS-CoV-2 testing and death records.Results: People infected with COVID-19 had more than three times the risk of dying over the following year compared with those who remained uninfected. Short-term mortality (up to 5 weeks post-infection) was significantly higher among COVID-19 patients (1623/10 000) than controls (118/10 000). For COVID-19 cases over 60 years old, increased mortality persisted until the end of the first year after infection, and was related to increased risk for cardiovascular (aHR 2·1, 95%CI 1·8-2·3), cancer (aHR 1·5, 95%CI 1·2-1·9), respiratory system diseases (aHR 1·9, 95%CI 1·2-3·0), and other causes of death (aHR 1·8, 95%CI 1·4-2·2).Conclusions: Increased risk of death from COVID-19 is not limited to the acute illness· COVID-19 infection carries a substantially increased risk of death in the following 12 months. This excess death mainly occurs in older people and is driven by broad array of causes of death.Funding Information: Research was carried out with the support of Estonian Research Council, European Regional Development Fund and European Social Fund via IT Academy program. Declaration of Interests: The authors report no conflicts of interest.Ethics Approval Statement: The study was approved by the Research Ethics Committee of the University of Tartu
Language:
English
DOI:
10.2139/ssrn.4028547