Format:
21
,
Illustrationen
ISSN:
1432-0533
Content:
Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0-14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with copy number, RNA-seq, and ChIP-seq analysis to characterize a newly identified CNS tumor type. In addition, we report histology, patient characteristics, and survival data in this tumor type. We describe a biologically distinct pediatric CNS tumor type (n = 31 cases) that is characterized by focal high-level amplification and resultant overexpression of either PLAGL1 or PLAGL2, and an absence of recurrent genetic alterations characteristic of other pediatric CNS tumor types. ...
Note:
Online veröffentlicht: 27. November 2022
,
Gesehen am 06.12.2023
In:
Acta neuropathologica, Berlin : Springer, 1961, 145(2023), 1, Seite 49-69, 1432-0533
In:
volume:145
In:
year:2023
In:
number:1
In:
pages:49-69
In:
extent:21
Language:
English
DOI:
10.1007/s00401-022-02516-2
URL:
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