Format:
Online-Ressource (374 p)
ISBN:
9780123914941
Content:
Behavioral Epigenetics is the study of how environmental factors affect alterations in behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcome. With an understanding of the molecular mechanisms involved in epigenetic modulation, researchers believe it will be possible to develop targeted therapies for those individuals in whom it malfunctions. This volume will address current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior
Note:
Description based upon print version of record
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Front Cover; Epigenetic Regulation in the Nervous System; Copyright Page; Contents; Preface; List of Contributors; 1 An Overview of the Molecular Basis of Epigenetics; Introduction; What is Epigenetics?; How Neuroepigenetics Differs from Traditional Epigenetics; Epigenetics and the Historical Debate of Nature vs Nurture; What are the Epigenetic Marks and What do they do?; DNA Modifications; Covalent Modification of DNA - Cytosine Methylation; Methylation Regulates Transcription through Multiple Mechanisms; Active Regulation of DNA Demethylation; Other Forms of DNA Methylation
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Histone ModificationsAcetylation; Methylation; Ubiquitination; Phosphorylation; Histone Subunit Exchange; A Histone Code for Regulating CNS Function?; Other Mechanisms of Epigenetic Tagging in the CNS; Non-Coding RNAs; Non-Genic DNA; Prion-Based Epigenetic Inheritance; Epigenome Organization and Higher Order Chromatin Structures; Roles for Epigenetic Mechanisms in the Nervous System; Epigenetic Mechanisms in Nervous System Development; Neurogenesis in the Adult CNS; Circadian Rhythms; Persisting Effects of Life Experience: Nurturing and Transgenerational Effects
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Epigenetic Mechanisms and Cellular Information StorageHuman Cognition and Cognitive Disorders; Summary - Active Regulation of Epigenetic Marks in the Nervous System; References; 2 Histone Modifications in the Nervous System and Neuropsychiatric Disorders; Introduction; The Histone Code: Complex and Combinatorial; Other Epigenetic Mechanisms; Summary; The Histone Code in Learning, Memory and Synaptic Plasticity; Histone Acetylation; Histone Phosphorylation; Histone Methylation; The Histone Code in Neurological and Neuropsychiatric Disorders
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Neurodevelopmental Disorders and Intellectual DisabilityRubinstein-Taybi Syndrome; ATR-X Syndrome; Addiction; Schizophrenia; Mood Disorders; Depression; Bipolar Disorder; Aging; Summary; Acknowledgments; References; 3 Active DNA Demethylation and 5-Hydroxymethylcytosine; Introduction; Regulation of Neuronal Gene Expression by Active DNA Demethylation; Active DNA Demethylation Mediated by DNA Repair; TET Proteins and an Oxidative Demethylation Pathway; Functions of TET Proteins and 5hmC Beyond DNA Demethylation; Role of Active DNA Demethylation in Neurological Disorders?; Concluding Remarks
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References4 The Epigenetics of Parental Effects; Overview; Parent-Offspring Interactions and the Mental Health of the Offspring; Evolutionary Biology of Parental Signaling; The Biology of Parent Influences; Molecular Transduction of Maternal Signals; The Epigenetics of Parental Effects; 5-hydroxymethylation; Methylation and GR Transcription; HDAC Inhibitors Reverse the Effect of Maternal Care; Developmental Regulation of Hippocampal GR Expression in Humans; Reversibility of DNA Methylation; Non-Genomic Transmission of Traits from Parent to Offspring
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Transgenerational Transmission of Individual Differences in Maternal Behavior
Additional Edition:
9780123944054
Additional Edition:
9780123914941
Additional Edition:
Erscheint auch als Druck-Ausgabe Epigenetic Regulation in the Nervous System : Basic Mechanisms and Clinical Impact
Language:
English
Keywords:
Electronic books
URL:
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